MARROW-STEM™ Bone Marrow Aspiration Device
MARROW-STEM™ bone marrow aspiration device is a minimally invasive procedure that leverages patented technology to extract high-quality stem and progenitor cells from various areas within the marrow space, while reducing the risk of peripheral blood contamination.
Marrow Aspiration to Application – Minimal Manipulation
The MARROW-STEM™ Bone Marrow Aspiration System is designed for autologous bone marrow aspiration and optimizes the collection of stem and progenitor cells. It enables the user to aspirate in a precise and controlled manner across a broad area within the marrow space. Additionally, it comes in various lengths and is intended for use in the Iliac Crest, Pedicle, Calcaneus, or Tibia.
What Are the Limitations of a Traditional Trocar?
Traditional bone marrow aspiration needles typically aspirate through an open-ended cannula. As fluid under pressure follows the path of least resistance, this method results in excessive peripheral blood contamination and insufficient collection of essential stem and progenitor cells, leading to a reduced overall cellular yield. Consequently, large volumes of bone marrow aspirate must be gathered from multiple sites and then manipulated (e.g., centrifuged or chemically separated in a lab) before being used in regenerative therapies.
How Does the MARROW-STEM™ System Overcome These Limitations?
The innovative design of the MARROW-STEM™ Aspiration System incorporates two key features that maximize cellular yield, minimize patient discomfort, and reduce the time needed to achieve optimal results, all while preserving the sterile field.
- The closed-tip aspiration cannula limits aspiration to the side holes of the cannula, avoiding the channel created by the needle tip and reducing peripheral blood infiltration.
- Integrated technology allows precise repositioning of the harvesting cannula within the marrow space after each aspiration. This enables controlled retraction of the cannula to collect bone marrow aspirate from multiple regions of the medullary space with a single puncture, meeting the clinician’s preference for a single entry point while enhancing patient comfort.
MARROW-STEM™ Provides a Greater Cell Yield
Marrow stem cells play a crucial role in tissue healing as part of the patient’s immune system, and only marrow stem cells have the strength to regenerate an entire immune system in an oncology context. By releasing cytokines and facilitating cell-to-cell interactions, bone marrow stem cells manage the shift from inflammation to proliferation and remodeling during the healing process. Mechanically harvesting and positioning the cells responsible for this transition effectively mirrors and enhances the body’s natural healing mechanisms.
Key Benefits
01
Cost-Effective & High-Yield
MARROW-STEM™ provides a superior regenerative solution, delivering more stem cells at a lower cost than other leading options.
02
Maximizes Stem-Cell Retention
Unlike centrifugation, which discards up to 80% of aspirate and 40% of key cells, MARROW-STEM™ preserves a higher concentration for optimal regeneration.
03
Enhanced Sterility & Safety
By eliminating off-field processing, MARROW-STEM™ reduces infection risks and maintains sterility throughout the procedure.
04
Faster & More Efficient
Requiring only one penetration and no centrifugation, MARROW-STEM™ reduces procedure time and eliminates the need for extra personnel.
05
Preserves Regenerative Potential
Unlike traditional methods that filter out valuable cell aggregates, MARROW-STEM™ retains them for direct application, maximizing healing potential.
Dr. Dan Kuebler Professor of Biology, Chair of the Biology Department; Franciscan University
A larger-volume of aspirate (more than 2mL) from a given site is contraindicated with the additional volume contributing little to the overall number of bone-marrow cells and results principally in unnecessary blood loss.
MUSCHLER G, et al Aspiration to Obtain Osteoblast Progenitor Cells from Human Bone Marrow: The Influence of “Aspiration Volume The Journal of Bone and Joint Surgery;” VOL. 79-A, NO. 11 Cleveland Clinic
